6-Bromo-8-cyclopentyl-5-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one
6-Bromo-8-cyclopentyl-5-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one(CAS 362656-25-5,货号C1768833)的哌柏西利相关产品资料,可核对 ...
哌柏西利(Palbociclib)抑制细胞周期蛋白依赖性激酶CDK4和CDK6,可阻断细胞从G1期进入S期;公开乳腺癌模型资料讨论了Rb磷酸化及E2F信号变化。
其结构含环戊基取代的吡啶并嘧啶酮、乙酰基及哌嗪基吡啶片段,区别于其他CDK4/6抑制剂的化学骨架。
参考资料:IBRANCE (PALBOCICLIB) TABLET, FILM COATED [U.S. PHARMACEUTICALS]